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Depression in autoimmune diseases


Pryce, Christopher R; Fontana, Adriano (2016). Depression in autoimmune diseases. In: Dantzer, Robert; Capuron, Lucile. Inflammation-Associated Depression: Evidence, Mechanisms and Implications. Cham: Springer, 139-154.

Abstract

Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. This review focuses on the different pathways involved in the communication of the immune system with the neuronal network and the body's timing system. The latter is built up by a hierarchically organized expression of clock genes. As discussed here, the activation of the immune system interferes with high amplitude expression of clock genes, an effect which may play a pivotal role in depression-like behavior in autoimmune diseases.

Abstract

Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. This review focuses on the different pathways involved in the communication of the immune system with the neuronal network and the body's timing system. The latter is built up by a hierarchically organized expression of clock genes. As discussed here, the activation of the immune system interferes with high amplitude expression of clock genes, an effect which may play a pivotal role in depression-like behavior in autoimmune diseases.

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Additional indexing

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:25 May 2016
Deposited On:18 May 2017 13:38
Last Modified:25 May 2017 00:00
Publisher:Springer
Series Name:Current Topics in Behavioral Neurosciences
Number:31
ISSN:1866-3370
ISBN:978-3-319-51151-1
Funders:SNSF
Publisher DOI:https://doi.org/10.1007/7854_2016_7
PubMed ID:27221625

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