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Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals


Schroeder, Clemens; Park, Min Tae M; Germann, Jürgen; Chakravarty, Mallar M; Michels, Lars; Kollias, Spyros; Kroll, Sara; Buck, Alfred; Treyer, Valerie; Savaskan, E; Unschuld, Paul G; Nitsch, Roger M; Kälin, Andrea M; Hock, Christoph; Gietl, Anton F; Leh, Sandra E (2017). Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals. European Journal of Neuroscience, 45(10):1241-1251.

Abstract

Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11-C-Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (p < 0.05, FDR-corrected), whereas volumes of the hippocampi and their subregions were not associated with the cortical measurement or uptake in the other regions (all p > 0.05, FDR-corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical uptake (p < 0.05, FDR-corrected). Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease. This article is protected by copyright. All rights reserved.

Abstract

Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11-C-Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (p < 0.05, FDR-corrected), whereas volumes of the hippocampi and their subregions were not associated with the cortical measurement or uptake in the other regions (all p > 0.05, FDR-corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical uptake (p < 0.05, FDR-corrected). Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease. This article is protected by copyright. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neuroradiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2017
Deposited On:26 Sep 2016 07:09
Last Modified:08 Dec 2017 20:25
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0953-816X
Publisher DOI:https://doi.org/10.1111/ejn.13408
PubMed ID:27646656

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