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Near-infrared image reconstruction of newborns' brains: robustness to perturbations of the source/detector location


Ahnen, L; Wolf, M; Hagmann, C; Sanchez, S (2016). Near-infrared image reconstruction of newborns' brains: robustness to perturbations of the source/detector location. Advances in Experimental Medicine and Biology, 876:377-82.

Abstract

The brain of preterm infants is the most vulnerable organ and can be severely injured by cerebral ischemia. We are working on a near-infrared imager to early detect cerebral ischemia. During imaging of the brain, movements of the newborn infants are inevitable and the near-infrared sensor has to be able to function on irregular geometries. Our aim is to determine the robustness of the near-infrared image reconstruction to small variations of the source and detector locations. In analytical and numerical simulations, the error estimations for a homogeneous medium agree well. The worst case estimates of errors in reduced scattering and absorption coefficient for distances of r=40 mm are acceptable for a single source-detector pair. The optical properties of an inhomogeneity representing an ischemia are reconstructed correctly within a homogeneous medium, if the error in placement is random.

Abstract

The brain of preterm infants is the most vulnerable organ and can be severely injured by cerebral ischemia. We are working on a near-infrared imager to early detect cerebral ischemia. During imaging of the brain, movements of the newborn infants are inevitable and the near-infrared sensor has to be able to function on irregular geometries. Our aim is to determine the robustness of the near-infrared image reconstruction to small variations of the source and detector locations. In analytical and numerical simulations, the error estimations for a homogeneous medium agree well. The worst case estimates of errors in reduced scattering and absorption coefficient for distances of r=40 mm are acceptable for a single source-detector pair. The optical properties of an inhomogeneity representing an ischemia are reconstructed correctly within a homogeneous medium, if the error in placement is random.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:27 Sep 2016 12:27
Last Modified:08 Dec 2017 20:26
Publisher:Springer
ISSN:0065-2598
Publisher DOI:https://doi.org/10.1007/978-1-4939-3023-4_47
PubMed ID:26782235

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