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Genetics and genomic basis of sleep in healthy humans


Landolt, Hans-Peter; Dijk, D J (2017). Genetics and genomic basis of sleep in healthy humans. In: Kryger, M H; Roth, T; Dement, WC. Principles and Practice in Sleep Medicine. Philadelphia: Elsevier, 310-321.

Abstract

Chapter Highlights
* Distinct characteristics of human sleep are regulated by different molecular and genetic mechanisms with different degrees of heritability.
* The genetics of sleep and sleep‐wake regulation are still relatively unknown when compared to the genetics of other complex traits.
* The sleep EEG is one of the most heritable traits in humans. Elucidating the underlying genes may reveal novel sleep functions.
* Independent replication and confirmation of most of currently proposed genetic associations with distinct characteristics of sleep and sleep regulatory processes in high‐quality protocols and data sets is required.

Abstract

Chapter Highlights
* Distinct characteristics of human sleep are regulated by different molecular and genetic mechanisms with different degrees of heritability.
* The genetics of sleep and sleep‐wake regulation are still relatively unknown when compared to the genetics of other complex traits.
* The sleep EEG is one of the most heritable traits in humans. Elucidating the underlying genes may reveal novel sleep functions.
* Independent replication and confirmation of most of currently proposed genetic associations with distinct characteristics of sleep and sleep regulatory processes in high‐quality protocols and data sets is required.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:11 February 2017
Deposited On:10 Jan 2017 08:14
Last Modified:11 Feb 2017 01:01
Publisher:Elsevier
Number:6
ISBN:9780323242882
Official URL:http://www.us.elsevierhealth.com/principles-and-practice-of-sleep-medicine-9780323242882.html
Other Identification Number:eBook ISBN 9780323377515

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