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Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area


Gavrilov, Y V; Ellison, B A; Yamamoto, M; Reddy, H; Haybaeck, J; Mignot, E; Baumann, C R; Scammell, T E; Valko, P O (2016). Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area. Sleep, 39(5):1059-1062.

Abstract

STUDY OBJECTIVES To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. METHODS Postmortem examination of five narcolepsy and eight control brains. RESULTS VLPO galanin neuron count did not differ between narcolepsy patients (11,151 ± 3,656) and controls (13,526 ± 9,544). CONCLUSIONS A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.

Abstract

STUDY OBJECTIVES To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. METHODS Postmortem examination of five narcolepsy and eight control brains. RESULTS VLPO galanin neuron count did not differ between narcolepsy patients (11,151 ± 3,656) and controls (13,526 ± 9,544). CONCLUSIONS A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 May 2016
Deposited On:29 Dec 2016 08:05
Last Modified:01 Jan 2017 06:14
Publisher:American Academy of Sleep Medicine
ISSN:0161-8105
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.5665/sleep.5754
PubMed ID:26951397

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