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Rituximab induces clonal expansion of IgG memory B-cells in patients with inflammatory central nervous system demyelination


Maurer, M A; Tuller, F; Gredler, V; Berger, T; Lutterotti, A; Lünemann, J D; Reindl, M (2016). Rituximab induces clonal expansion of IgG memory B-cells in patients with inflammatory central nervous system demyelination. Journal of Neuroimmunology, 290:49-53.

Abstract

Rituximab, a monoclonal B-cell cytolytic antibody, has beneficial effects in patients with inflammatory demyelinating diseases. So far, little data exists on B-cell subset recovery after rituximab treatment in inflammatory demyelinating diseases of the central nervous system (CNS). To elucidate whether rituximab promotes qualitative changes in the IgG memory B-cell repertoire we performed a single cell analysis in three patients with CNS demyelination. We did not observe any qualitative changes but detected an increased clonal expansion in the IgG memory B-cell compartment after treatment, indicating that a single course of rituximab does not eliminate specific IgG memory B-cells.

Abstract

Rituximab, a monoclonal B-cell cytolytic antibody, has beneficial effects in patients with inflammatory demyelinating diseases. So far, little data exists on B-cell subset recovery after rituximab treatment in inflammatory demyelinating diseases of the central nervous system (CNS). To elucidate whether rituximab promotes qualitative changes in the IgG memory B-cell repertoire we performed a single cell analysis in three patients with CNS demyelination. We did not observe any qualitative changes but detected an increased clonal expansion in the IgG memory B-cell compartment after treatment, indicating that a single course of rituximab does not eliminate specific IgG memory B-cells.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:15 January 2016
Deposited On:18 Nov 2016 09:28
Last Modified:04 Dec 2016 06:26
Publisher:Elsevier
ISSN:0165-5728
Publisher DOI:https://doi.org/10.1016/j.jneuroim.2015.11.006
PubMed ID:26711569

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