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Evaluation of substituted 1,2,3-Dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism.


Asquith, Christopher R M; Konstantinova, Lidia S; Laitinen, Tuomo; Meli, Marina L; Poso, Antti; Rakitin, Oleg A; Hofmann-Lehmann, Regina; Hilton, Stephen T (2016). Evaluation of substituted 1,2,3-Dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism. ChemMedChem, 11(19):2119-2126.

Abstract

A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.

Abstract

A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:FIV; HIV-1; homology models; nucleocapsid protein; zinc abstraction; zinc ejection
Language:English
Date:6 October 2016
Deposited On:28 Nov 2016 10:54
Last Modified:29 Nov 2016 08:48
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1860-7179
Publisher DOI:https://doi.org/10.1002/cmdc.201600260
PubMed ID:27511289

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