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Sensitivity of transmission probabilities to paternity exclusion in segregation analysis


Bonaïti-Pellié, C; Poisson, N; Bechtel, Y; Bechtel, P (1992). Sensitivity of transmission probabilities to paternity exclusion in segregation analysis. Genetic Epidemiology, 9(1):67-71.

Abstract

Paternity exclusions are known to be common in Western countries and are yet neglected in segregation analysis because it is almost impossible to check it systematically on a large family sample. We had the opportunity of observing the sensitivity of segregation analysis parameters to a paternity exclusion in analyzing 34 families for a simple Mendelian trait, the acetylator phenotype. We found that only one family, with proven paternity exclusion, was responsible for a strong rejection of Mendelian transmission probabilities (P much much less than 0.001).

Abstract

Paternity exclusions are known to be common in Western countries and are yet neglected in segregation analysis because it is almost impossible to check it systematically on a large family sample. We had the opportunity of observing the sensitivity of segregation analysis parameters to a paternity exclusion in analyzing 34 families for a simple Mendelian trait, the acetylator phenotype. We found that only one family, with proven paternity exclusion, was responsible for a strong rejection of Mendelian transmission probabilities (P much much less than 0.001).

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7 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Language:German
Date:1992
Deposited On:17 Mar 2009 10:57
Last Modified:05 Apr 2016 12:58
Publisher:Wiley-Blackwell
ISSN:0741-0395
Publisher DOI:https://doi.org/10.1002/gepi.1370090108
Related URLs:http://opac.nebis.ch/F/?local_base=NEBIS&con_lng=GER&func=find-b&find_code=SYS&request=004295542
PubMed ID:1634108

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