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Regulatory roles of mast cells in immune responses


Morita, Hideaki; Saito, Hirohisa; Matsumoto, Kenji; Nakae, Susumu (2016). Regulatory roles of mast cells in immune responses. Seminars in Immunopathology, 38(5):623-629.

Abstract

Mast cells are important immune cells for host defense through activation of innate immunity (via toll-like receptors or complement receptors) and acquired immunity (via FcεRI). Conversely, mast cells also act as effector cells that exacerbate development of allergic or autoimmune disorders. Yet, several lines of evidence show that mast cells act as regulatory cells to suppress certain inflammatory diseases. Here, we review the mechanisms by which mast cells suppress diseases.

Abstract

Mast cells are important immune cells for host defense through activation of innate immunity (via toll-like receptors or complement receptors) and acquired immunity (via FcεRI). Conversely, mast cells also act as effector cells that exacerbate development of allergic or autoimmune disorders. Yet, several lines of evidence show that mast cells act as regulatory cells to suppress certain inflammatory diseases. Here, we review the mechanisms by which mast cells suppress diseases.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:05 Dec 2016 11:44
Last Modified:02 Feb 2018 10:50
Publisher:Springer
ISSN:1863-2297
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00281-016-0566-0
PubMed ID:27154294

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