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Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions


Chiotellis, Aristeidis; Sladojevich, Filippo; Mu, Linjing; Müller Herde, Adrienne; Valverde, Ibai E; Tolmachev, Vladimir; Schibli, Roger; Ametamey, Simon M; Mindt, Thomas L (2016). Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions. Chemical Communications, 52(36):6083-6086.

Abstract

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

Abstract

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:4 May 2016
Deposited On:05 Dec 2016 14:10
Last Modified:11 Dec 2016 06:37
Publisher:Royal Society of Chemistry
ISSN:1359-7345
Publisher DOI:https://doi.org/10.1039/c6cc01982j
PubMed ID:27043419

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