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Statin use and risk of cholecystectomy - A case-control analysis using Swiss claims data


Biétry, Fabienne A; Reich, Oliver; Schwenkglenks, Matthias; Meier, Christoph R (2016). Statin use and risk of cholecystectomy - A case-control analysis using Swiss claims data. Expert Opinion on Drug Safety, 15(12):1577-1582.

Abstract

OBJECTIVES: Using claims data from the Helsana Group, a large Swiss health insurance provider, we examined the association between statin use and the risk of cholecystectomy in a case-control analysis.
METHODS: We identified 2,200 cholecystectomy cases between 2013 and 2014 and matched 4 controls to each case on age, sex, index date and canton. We categorized statin users into current or past users (last prescription ≤ 180 or > 180 days before the index date, respectively) and classified medication use by duration based on number of prescriptions before the index date. We applied conditional logistic regression analyses to calculate odds ratios (ORs) with 95% confidence intervals (CIs) and adjusted the analyses for history of cardiovascular diseases and for use of estrogens, fibrates and other lipid-lowering agents.
RESULTS: The adjusted OR (aOR) for cholecystectomy was 0.85 (95% CI: 0.74, 0.99) for current statin users compared to non-users. Long-term current statin use (5-19 prescriptions) was associated with a reduced OR (aOR 0.77, 95% CI: 0.65, 0.92). However, neither short-term current use nor past statin use affected the risk of cholecystectomy.
CONCLUSIONS: The study supports the previously raised hypothesis that long-term statin use reduces the risk of cholecystectomy.

Abstract

OBJECTIVES: Using claims data from the Helsana Group, a large Swiss health insurance provider, we examined the association between statin use and the risk of cholecystectomy in a case-control analysis.
METHODS: We identified 2,200 cholecystectomy cases between 2013 and 2014 and matched 4 controls to each case on age, sex, index date and canton. We categorized statin users into current or past users (last prescription ≤ 180 or > 180 days before the index date, respectively) and classified medication use by duration based on number of prescriptions before the index date. We applied conditional logistic regression analyses to calculate odds ratios (ORs) with 95% confidence intervals (CIs) and adjusted the analyses for history of cardiovascular diseases and for use of estrogens, fibrates and other lipid-lowering agents.
RESULTS: The adjusted OR (aOR) for cholecystectomy was 0.85 (95% CI: 0.74, 0.99) for current statin users compared to non-users. Long-term current statin use (5-19 prescriptions) was associated with a reduced OR (aOR 0.77, 95% CI: 0.65, 0.92). However, neither short-term current use nor past statin use affected the risk of cholecystectomy.
CONCLUSIONS: The study supports the previously raised hypothesis that long-term statin use reduces the risk of cholecystectomy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:December 2016
Deposited On:01 Dec 2016 08:28
Last Modified:08 Dec 2017 21:09
Publisher:Taylor & Francis
ISSN:1474-0338
Publisher DOI:https://doi.org/10.1080/14740338.2016.1240782
PubMed ID:27677561

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