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Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV


Ferrantelli, Flavia; Rasmussen, Robert A; Hofmann-Lehmann, Regina; Xu, Weidong; McClure, Harold M; Ruprecht, Ruth M (2002). Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV. Vaccine, 20(Suppl 4):A61-A65.

Abstract

Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prevented infection in primates, indicating that epitopes recognized by such nmAbs are key determinants for protection. Lastly, in the absence of CD8+ T cells, nAbs may act as a second line of defense during chronic infection. Taken together, these results argue for generating nAb response-based prophylactic and/or therapeutic AIDS vaccines. We suggest that the epitopes identified by passive immunization represent excellent targets for the rational design of nAb response-based AIDS vaccines.

Abstract

Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prevented infection in primates, indicating that epitopes recognized by such nmAbs are key determinants for protection. Lastly, in the absence of CD8+ T cells, nAbs may act as a second line of defense during chronic infection. Taken together, these results argue for generating nAb response-based prophylactic and/or therapeutic AIDS vaccines. We suggest that the epitopes identified by passive immunization represent excellent targets for the rational design of nAb response-based AIDS vaccines.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:19 December 2002
Deposited On:30 Nov 2016 13:31
Last Modified:23 Nov 2017 00:59
Publisher:Elsevier
ISSN:0264-410X
Publisher DOI:https://doi.org/10.1016/S0264-410X(02)00389-4
PubMed ID:12477430

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