Header

UZH-Logo

Maintenance Infos

Acid-base status in healthy volunteers: Reliability of the venous blood titration method according to Joergensen and van Limburg Stirum


Melchart, D; Doerfler, W; Weidenhammer, W; Eustachi, A (2016). Acid-base status in healthy volunteers: Reliability of the venous blood titration method according to Joergensen and van Limburg Stirum. European Journal of Integrative Medicine, 8(6):965-972.

Abstract

Introduction In complementary medicine, chronic, subclinical imbalance of acid-base regulation is considered a risk factor for chronic diseases. It is, however, unclear how this can be detected diagnostically.The objective was to study the reliability of an acid-base titration method according to Joergensen and van Limburg Stirum. Method The pH values before and after gradual titration using HCl was measured in two venous blood samples (day-1 and day-3) in healthy volunteers (n = 57). The blood test on day 3 was analysed twice. Results Data could was available from 48 subjects. Comparison of data from day 1 and day 3 showed a statistically significant difference in the blood pH before titration with average values of 7.45 (day 1) and 7.46 (day 3), respectively. Comparison of day 3/measurement 1 with day 3/measurement 2 showed no significant differences in the blood pH values. Conclusion The difference between days 1 and 3 is likely due to changes in setting factors which could not be controlled for. The blood titration method according to Joergensen and van Limburg Stirum seems to have an acceptable retest-reliability.

Abstract

Introduction In complementary medicine, chronic, subclinical imbalance of acid-base regulation is considered a risk factor for chronic diseases. It is, however, unclear how this can be detected diagnostically.The objective was to study the reliability of an acid-base titration method according to Joergensen and van Limburg Stirum. Method The pH values before and after gradual titration using HCl was measured in two venous blood samples (day-1 and day-3) in healthy volunteers (n = 57). The blood test on day 3 was analysed twice. Results Data could was available from 48 subjects. Comparison of data from day 1 and day 3 showed a statistically significant difference in the blood pH before titration with average values of 7.45 (day 1) and 7.46 (day 3), respectively. Comparison of day 3/measurement 1 with day 3/measurement 2 showed no significant differences in the blood pH values. Conclusion The difference between days 1 and 3 is likely due to changes in setting factors which could not be controlled for. The blood titration method according to Joergensen and van Limburg Stirum seems to have an acceptable retest-reliability.

Statistics

Altmetrics

Downloads

1 download since deposited on 21 Dec 2016
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Complementary Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2 November 2016
Deposited On:21 Dec 2016 09:41
Last Modified:08 Dec 2017 21:30
Publisher:Elsevier
ISSN:1876-3820
Publisher DOI:https://doi.org/10.1016/j.eujim.2016.11.002

Download