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Full-length nucleotide sequences of mcr-1 harboring plasmids isolated from extended-spectrum β-lactamase (ESBL)- producing Escherichia coli of different origins


Zurfluh, Katrin; Klumpp, Jochen; Nüesch-Inderbinen, Magdalena; Stephan, Roger (2016). Full-length nucleotide sequences of mcr-1 harboring plasmids isolated from extended-spectrum β-lactamase (ESBL)- producing Escherichia coli of different origins. Antimicrobial Agents and Chemotherapy, 60(9):5589-5591.

Abstract

Here, we present the full sequences of three mcr-1-carrying plasmids isolated from extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli The plasmids belong to three different replicon types and are 34,640 bp, 209,401 bp, and 247,885 bp in size. We describe for the first time a composite transposon containing mcr-1 localized on a multidrug-resistant (MDR) IncHI2 plasmid harboring additional determinants of resistance to six different classes of antibiotics, including the ESBL gene blaCTX-M-1, and heavy metal resistance.

Abstract

Here, we present the full sequences of three mcr-1-carrying plasmids isolated from extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli The plasmids belong to three different replicon types and are 34,640 bp, 209,401 bp, and 247,885 bp in size. We describe for the first time a composite transposon containing mcr-1 localized on a multidrug-resistant (MDR) IncHI2 plasmid harboring additional determinants of resistance to six different classes of antibiotics, including the ESBL gene blaCTX-M-1, and heavy metal resistance.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Food Safety and Hygiene
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:20 June 2016
Deposited On:23 Jan 2017 08:58
Last Modified:03 Aug 2017 19:24
Publisher:American Society for Microbiology
ISSN:0066-4804
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/AAC.00935-16
PubMed ID:27324774

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