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Allergic contact dermatitis


Kostner, Lisa; Anzengruber, Florian; Guillod, Caroline; Recher, Mike; Schmid-Grendelmeier, Peter; Navarini, Alexander A (2017). Allergic contact dermatitis. Immunology and Allergy Clinics of North America, 37(1):141-152.

Abstract

Allergic contact dermatitis (ACD) is a common skin disease caused by a T cell-mediated immune reaction to usually innocuous allergens. ACD can have grave medical and socioeconomic consequences. ACD and irritant contact dermatitis often occur together. A detailed history and clinical examination are crucial and guide patch testing, which is the gold standard to diagnose ACD. T-cell clones persisting in the skin may explain the tendency of ACD to relapse even after years of allergen avoidance. Traditional treatments for ACD are topical steroids, calcineurin inhibitors, phototherapy, retinoids (including the recent alitretinoin), and immunosuppressants. Targeted therapies are lacking.

Abstract

Allergic contact dermatitis (ACD) is a common skin disease caused by a T cell-mediated immune reaction to usually innocuous allergens. ACD can have grave medical and socioeconomic consequences. ACD and irritant contact dermatitis often occur together. A detailed history and clinical examination are crucial and guide patch testing, which is the gold standard to diagnose ACD. T-cell clones persisting in the skin may explain the tendency of ACD to relapse even after years of allergen avoidance. Traditional treatments for ACD are topical steroids, calcineurin inhibitors, phototherapy, retinoids (including the recent alitretinoin), and immunosuppressants. Targeted therapies are lacking.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:February 2017
Deposited On:04 Jan 2017 10:54
Last Modified:29 Jan 2017 08:31
Publisher:Elsevier
ISSN:0889-8561
Publisher DOI:https://doi.org/10.1016/j.iac.2016.08.014
PubMed ID:27886903

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Embargo till: 2017-11-01

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