Header

UZH-Logo

Maintenance Infos

Syringomatous Structures in Extramammary Paget Disease: A Potential Diagnostic Pitfall


Konstantinova, Anastasia M; Hayes, Malcolm M; Stewart, Colin J R; Plaza, Jose A; Michal, Michal; Kerl, Katrin; Kazakov, Dmitry V (2016). Syringomatous Structures in Extramammary Paget Disease: A Potential Diagnostic Pitfall. American Journal of Dermatopathology, 38(9):653-657.

Abstract

Primary extramammary Paget disease (EMPD) is a form of intraepithelial adenocarcinoma. Different morphological changes may accompany EMPD, including the presence of syringoma-like structures. The authors report 10 cases of EMPD, all of which manifested syringoma-like structures within the dermis both in areas involved by the carcinoma and beyond, including at the margins of the excisions. All patients were women, whose ages ranged from 49 to 93 years (median 75 years). The possible pathogenesis of the syringoma-like lesions is discussed. Awareness of these structures in vulvectomy specimens for EMPD is important to prevent misinterpretation of the syringoma-like lesions as an invasive component of the EMPD.

Abstract

Primary extramammary Paget disease (EMPD) is a form of intraepithelial adenocarcinoma. Different morphological changes may accompany EMPD, including the presence of syringoma-like structures. The authors report 10 cases of EMPD, all of which manifested syringoma-like structures within the dermis both in areas involved by the carcinoma and beyond, including at the margins of the excisions. All patients were women, whose ages ranged from 49 to 93 years (median 75 years). The possible pathogenesis of the syringoma-like lesions is discussed. Awareness of these structures in vulvectomy specimens for EMPD is important to prevent misinterpretation of the syringoma-like lesions as an invasive component of the EMPD.

Statistics

Citations

4 citations in Web of Science®
4 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

5 downloads since deposited on 04 Jan 2017
5 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:September 2016
Deposited On:04 Jan 2017 11:31
Last Modified:08 Dec 2017 21:49
Publisher:Lippincott Williams & Wilkins
ISSN:0193-1091
Publisher DOI:https://doi.org/10.1097/DAD.0000000000000497
PubMed ID:26863060

Download

Download PDF  'Syringomatous Structures in Extramammary Paget Disease: A Potential Diagnostic Pitfall'.
Preview
Content: Published Version
Filetype: PDF
Size: 1MB
View at publisher