Header

UZH-Logo

Maintenance Infos

Reduced normal tissue dosis through advanced technology


Guckenberger, Matthias; Sweeney, Reinhart A; Panje, Cedric; Tanadini-Lang, Stephanie (2017). Reduced normal tissue dosis through advanced technology. In: Langendijk, Johannes; Nieder, Carsten. Re-Irradiation: New Frontiers. Cham: Springer, 75-103.

Abstract

Re-irradiation is probably the most challenging situation in radiotherapy because the radiation tolerance of the normal tissue is significantly reduced compared with the first treatment series. Results with traditional radiotherapy techniques have been disappointing because of the poor conformality of the dose distributions: radiation doses were either insufficiently low resulting in poor rates of tumor control or substantial toxicity was the consequence of high-dose re-irradiation. This chapter will focus on modern techniques of radiation treatment planning and delivery, which make improved sparing of the normal tissue possible. All techniques will be discussed in the context of re-irradiation and theoretical and clinical data supporting the use of these technologies will be presented. Palliative reirradiation to moderate doses might be feasible without using advanced technology. However, under many circumstances 2D or 3D conformal approaches cannot fulfill the required normal tissue constraints. The present chapter discusses the advantages and challenges associated with more complex planning and delivery methods.

Abstract

Re-irradiation is probably the most challenging situation in radiotherapy because the radiation tolerance of the normal tissue is significantly reduced compared with the first treatment series. Results with traditional radiotherapy techniques have been disappointing because of the poor conformality of the dose distributions: radiation doses were either insufficiently low resulting in poor rates of tumor control or substantial toxicity was the consequence of high-dose re-irradiation. This chapter will focus on modern techniques of radiation treatment planning and delivery, which make improved sparing of the normal tissue possible. All techniques will be discussed in the context of re-irradiation and theoretical and clinical data supporting the use of these technologies will be presented. Palliative reirradiation to moderate doses might be feasible without using advanced technology. However, under many circumstances 2D or 3D conformal approaches cannot fulfill the required normal tissue constraints. The present chapter discusses the advantages and challenges associated with more complex planning and delivery methods.

Statistics

Altmetrics

Additional indexing

Item Type:Book Section, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2017
Deposited On:16 Feb 2017 12:51
Last Modified:16 Feb 2017 13:21
Publisher:Springer
Series Name:Medical Radiology
ISSN:0942-5373
ISBN:978-3-319-41823-0
Additional Information:978-3-319-41825-4
Publisher DOI:https://doi.org/10.1007/174_2016_55
Related URLs:https://doi.org/10.1007/978-3-319-41825-4 (Publisher)

Download

Full text not available from this repository.
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations