Header

UZH-Logo

Maintenance Infos

Transition from one- to two-dimensional development facilitates maintenance of multicellularity


Manjarrez-Casas, Alejandra; Bagheri, Homayoun C; Dobay, Akos (2016). Transition from one- to two-dimensional development facilitates maintenance of multicellularity. Royal Society Open Science, 3(9):1-11.

Abstract

Filamentous organisms represent an example where incomplete separation after cell division underlies the development of multicellular formations. With a view to understanding the evolution of more complex multicellular structures, we explore the transition of multicellular growth from one to two dimensions. We develop a computational model to simulate multicellular development in populations where cells exhibit density-dependent division and death rates. In both the one- and two-dimensional contexts, multicellular formations go through a developmental cycle of growth and subsequent decay. However, the model shows that a transition to a higher dimension increases the size of multicellular formations and facilitates the maintenance of large cell clusters for significantly longer periods of time. We further show that the turnover rate for cell division and death scales with the number of iterations required to reach the stationary multicellular size at equilibrium. Although size and life cycles of multicellular organisms are affected by other environmental and genetic factors, the model presented here evaluates the extent to which the transition of multicellular growth from one to two dimensions contributes to the maintenance of multicellular structures during development.

Abstract

Filamentous organisms represent an example where incomplete separation after cell division underlies the development of multicellular formations. With a view to understanding the evolution of more complex multicellular structures, we explore the transition of multicellular growth from one to two dimensions. We develop a computational model to simulate multicellular development in populations where cells exhibit density-dependent division and death rates. In both the one- and two-dimensional contexts, multicellular formations go through a developmental cycle of growth and subsequent decay. However, the model shows that a transition to a higher dimension increases the size of multicellular formations and facilitates the maintenance of large cell clusters for significantly longer periods of time. We further show that the turnover rate for cell division and death scales with the number of iterations required to reach the stationary multicellular size at equilibrium. Although size and life cycles of multicellular organisms are affected by other environmental and genetic factors, the model presented here evaluates the extent to which the transition of multicellular growth from one to two dimensions contributes to the maintenance of multicellular structures during development.

Statistics

Altmetrics

Downloads

6 downloads since deposited on 12 Jan 2017
6 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:21 September 2016
Deposited On:12 Jan 2017 10:33
Last Modified:08 Dec 2017 22:02
Publisher:The Royal Society Publishing
ISSN:2054-5703
Funders:University Zurich
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1098/rsos.160554
Official URL:http://rsos.royalsocietypublishing.org/content/3/9/160554
Related URLs:http://datadryad.org/resource/doi:10.5061/dryad.bj0b2/1
PubMed ID:27703714
Other Identification Number:PMC5043334

Download

Download PDF  'Transition from one- to two-dimensional development facilitates maintenance of multicellularity'.
Preview
Content: Published Version
Filetype: PDF
Size: 805kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)