Header

UZH-Logo

Maintenance Infos

Risk factors for severity and manifestations in systemic sclerosis and prediction of disease course


Becker, Mike O; Riemekasten, Gabriela (2016). Risk factors for severity and manifestations in systemic sclerosis and prediction of disease course. Expert Review of Clinical Immunology, 12(2):115-135.

Abstract

Systemic sclerosis (SSc, or scleroderma) is a rheumatic disease with distinct features that encompass autoimmunity, vascular lesions (vasculopathy) and tissue fibrosis. The disease has a high morbidity and mortality compared with other rheumatic diseases. This review discusses risk factors and markers that predict the disease course and the occurrence of disease manifestations, with an emphasis on major organ involvement. In addition, risk factors will be described that are associated with mortality in SSc patients. The review addresses the impact of recent developments on screening, diagnosis and risk stratification as well as the need for further research where data are lacking.

Abstract

Systemic sclerosis (SSc, or scleroderma) is a rheumatic disease with distinct features that encompass autoimmunity, vascular lesions (vasculopathy) and tissue fibrosis. The disease has a high morbidity and mortality compared with other rheumatic diseases. This review discusses risk factors and markers that predict the disease course and the occurrence of disease manifestations, with an emphasis on major organ involvement. In addition, risk factors will be described that are associated with mortality in SSc patients. The review addresses the impact of recent developments on screening, diagnosis and risk stratification as well as the need for further research where data are lacking.

Statistics

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:12 Jan 2017 07:39
Last Modified:12 Jan 2017 07:41
Publisher:Expert Reviews
ISSN:1744-666X
Publisher DOI:https://doi.org/10.1586/1744666X.2016.1115717
PubMed ID:26558747

Download

Full text not available from this repository.
View at publisher