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Secondary electrospray ionization coupled to high-resolution mass spectrometry reveals tryptophan pathway metabolites in exhaled human breath


García-Gómez, Diego; Gaisl, Thomas; Bregy, Lukas; Martínez-Lozano Sinues, Pablo; Kohler, Malcolm; Zenobi, Renato (2016). Secondary electrospray ionization coupled to high-resolution mass spectrometry reveals tryptophan pathway metabolites in exhaled human breath. Chemical Communications, 52(55):8526-8528.

Abstract

Many studies and personalized medicine in general require frequent measurements and/or rapid results of biomarker levels. Here we show that 20 low volatility metabolites of the tryptophan pathway can be detected in exhaled human breath. This real-time and non-invasive method offers an attractive alternative to blood analysis.

Abstract

Many studies and personalized medicine in general require frequent measurements and/or rapid results of biomarker levels. Here we show that 20 low volatility metabolites of the tryptophan pathway can be detected in exhaled human breath. This real-time and non-invasive method offers an attractive alternative to blood analysis.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:30 June 2016
Deposited On:19 Jan 2017 15:57
Last Modified:22 Jan 2017 06:35
Publisher:Royal Society of Chemistry
ISSN:1359-7345
Publisher DOI:https://doi.org/10.1039/c6cc03070j
PubMed ID:27273568

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