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ATGs help MHC class II, but inhibit MHC class I antigen presentation


Loi, Monica; Gannagé, Monique; Münz, Christian (2016). ATGs help MHC class II, but inhibit MHC class I antigen presentation. Autophagy, 12(9):1681-1682.

Abstract

We have recently shown that the LC3/Atg8 lipidation machinery of macroautophagy is involved in the internalization of MHC class I molecules. Decreased internalization in the absence of ATG5 or ATG7 leads to MHC class I surface stabilization on dendritic cells and macrophages, resulting in elevated CD8(+) T cell responses during viral infections and improved immune control. Here, we discuss how the autophagic machinery supports MHC class II restricted antigen presentation, while compromising MHC class I presentation via internalization and degradation.

Abstract

We have recently shown that the LC3/Atg8 lipidation machinery of macroautophagy is involved in the internalization of MHC class I molecules. Decreased internalization in the absence of ATG5 or ATG7 leads to MHC class I surface stabilization on dendritic cells and macrophages, resulting in elevated CD8(+) T cell responses during viral infections and improved immune control. Here, we discuss how the autophagic machinery supports MHC class II restricted antigen presentation, while compromising MHC class I presentation via internalization and degradation.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2016
Deposited On:16 Jan 2017 12:31
Last Modified:16 Jan 2017 12:31
Publisher:Taylor & Francis
ISSN:1554-8627
Publisher DOI:https://doi.org/10.1080/15548627.2016.1203488
PubMed ID:27439741

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