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Intestinal and hepatocellular transporters: therapeutic effects and drug interactions of herbal supplements


Stieger, Bruno; Mahdi, Zainab M; Jäger, Walter (2017). Intestinal and hepatocellular transporters: therapeutic effects and drug interactions of herbal supplements. Annual Review of Pharmacology and Toxicology, 57(1):399-416.

Abstract

Herbal supplements are generally considered safe; however, drug disposition is influenced by the interactions of herbal supplements and food constituents with transport and metabolic processes. Although the interference of herbal supplements with drug metabolism has been studied extensively, knowledge of how they interact with the drug transport processes is less advanced. Therefore, we describe here specific examples of experimental and human interaction studies of herbal supplement components with drug transporters addressing, for example, organic anion transporting polypeptides or P-glycoprotein, as such interactions may lead to severe side effects and altered drug efficacy. Hence, it is clearly necessary to increase the awareness of the clinical relevance of the interference of herbal supplements with the drug transport processes.

Abstract

Herbal supplements are generally considered safe; however, drug disposition is influenced by the interactions of herbal supplements and food constituents with transport and metabolic processes. Although the interference of herbal supplements with drug metabolism has been studied extensively, knowledge of how they interact with the drug transport processes is less advanced. Therefore, we describe here specific examples of experimental and human interaction studies of herbal supplement components with drug transporters addressing, for example, organic anion transporting polypeptides or P-glycoprotein, as such interactions may lead to severe side effects and altered drug efficacy. Hence, it is clearly necessary to increase the awareness of the clinical relevance of the interference of herbal supplements with the drug transport processes.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2017
Deposited On:17 Jan 2017 13:59
Last Modified:17 Jan 2017 13:59
Publisher:Annual Reviews
ISSN:0362-1642
Publisher DOI:https://doi.org/10.1146/annurev-pharmtox-010716-105010
PubMed ID:27648763

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