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Prenatal and postnatal medical conditions and the risk of brain tumors in children and adolescents: an international multicenter case-control study


Tettamanti, Giorgio; Shu, Xiaochen; Adel Fahmideh, Maral; Schüz, Joachim; Röösli, Martin; Tynes, Tore; Grotzer, Michael; Johansen, Christoffer; Klaeboe, Lars; Kuehni, Claudia E; Lannering, Birgitta; Schmidt, Lisbeth S; Vienneau, Danielle; Feychting, Maria (2017). Prenatal and postnatal medical conditions and the risk of brain tumors in children and adolescents: an international multicenter case-control study. Cancer Epidemiology Biomarkers & Prevention, 26(1):110-115.

Abstract

BACKGROUND: Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have reported an increased risk associated with exposure to head CT scans.
METHODS: Information regarding medical conditions, including prenatal and postnatal exposure to medical diagnostic radiation, was obtained from CEFALO, a multicenter case-control study performed in Denmark, Norway, Sweden, and Switzerland through face-to-face interview. Eligible cases of childhood and adolescent brain tumors (CABT) were ages 7 to 19 years, diagnosed between January 1, 2004 and August 31, 2008, and living in the participating countries (n = 352). The cases were matched by age, sex, and region to 646 population-based controls.
RESULTS: Prenatal exposure to medical diagnostic radiation and postnatal exposure to X-rays were not associated with CABTs. A higher risk estimate of CABTs, although not statistically significant, was found for exposure to head CT scan (OR, 1.86; 95% confidence interval, 0.82-4.22). The associations with head injury, febrile seizure, fever in the first 12 weeks, and general anesthesia were close to unity.
CONCLUSIONS: Prenatal or postnatal medical conditions, including medical diagnostic radiation, were not associated with CABTs. On the basis of small numbers of exposed children, we observed a nonsignificant increased risk for CT scans of the head.
IMPACT: We have presented additional evidence, suggesting that exposure to head CT scan may be associated with the occurrence of CABTs.

Abstract

BACKGROUND: Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have reported an increased risk associated with exposure to head CT scans.
METHODS: Information regarding medical conditions, including prenatal and postnatal exposure to medical diagnostic radiation, was obtained from CEFALO, a multicenter case-control study performed in Denmark, Norway, Sweden, and Switzerland through face-to-face interview. Eligible cases of childhood and adolescent brain tumors (CABT) were ages 7 to 19 years, diagnosed between January 1, 2004 and August 31, 2008, and living in the participating countries (n = 352). The cases were matched by age, sex, and region to 646 population-based controls.
RESULTS: Prenatal exposure to medical diagnostic radiation and postnatal exposure to X-rays were not associated with CABTs. A higher risk estimate of CABTs, although not statistically significant, was found for exposure to head CT scan (OR, 1.86; 95% confidence interval, 0.82-4.22). The associations with head injury, febrile seizure, fever in the first 12 weeks, and general anesthesia were close to unity.
CONCLUSIONS: Prenatal or postnatal medical conditions, including medical diagnostic radiation, were not associated with CABTs. On the basis of small numbers of exposed children, we observed a nonsignificant increased risk for CT scans of the head.
IMPACT: We have presented additional evidence, suggesting that exposure to head CT scan may be associated with the occurrence of CABTs.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:January 2017
Deposited On:23 Jan 2017 16:28
Last Modified:23 Jan 2017 16:28
Publisher:American Association for Cancer Research
ISSN:1055-9965
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1158/1055-9965.EPI-16-0451
PubMed ID:27624640

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