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Late stages of the influenza A virus replication cycle — a tight interplay between virus and host


Pohl, M O; Lanz, C; Stertz, S (2016). Late stages of the influenza A virus replication cycle — a tight interplay between virus and host. Journal of General Virology, 97(9):2058 -2072.

Abstract

Influenza A virus (IAV) is the causative agent of a febrile illness in humans, commonly referred to as‘the flu’. IAV causes seasonal epidemics and sporadic pandemics, imposing a huge burden on human health and economy. IAV are enveloped viruses belonging to the family of Orthomyxoviridae, whose members are characterized by a single-stranded segmented RNA genome of negative polarity (Palese & Shaw, 2007). Unlike most other RNA viruses, orthomyxoviruses replicate in the nucleus of the infected cell (Cros & Palese, 2003). While nuclear replication confers several advantages, such as access to the cellular splicing machinery, the virus faces the challenge of overcoming the nuclear envelope. Due to its small genome size of 13.5 kb, IAV relies heavily on cellular factors to complete its life cycle. In this review we focus on late stages of infection and describe the interplay between the virus and its host in the process of vRNP nuclear export, transport of viral proteins to the assembly site, genome packaging, as well as budding and release of virions.

Abstract

Influenza A virus (IAV) is the causative agent of a febrile illness in humans, commonly referred to as‘the flu’. IAV causes seasonal epidemics and sporadic pandemics, imposing a huge burden on human health and economy. IAV are enveloped viruses belonging to the family of Orthomyxoviridae, whose members are characterized by a single-stranded segmented RNA genome of negative polarity (Palese & Shaw, 2007). Unlike most other RNA viruses, orthomyxoviruses replicate in the nucleus of the infected cell (Cros & Palese, 2003). While nuclear replication confers several advantages, such as access to the cellular splicing machinery, the virus faces the challenge of overcoming the nuclear envelope. Due to its small genome size of 13.5 kb, IAV relies heavily on cellular factors to complete its life cycle. In this review we focus on late stages of infection and describe the interplay between the virus and its host in the process of vRNP nuclear export, transport of viral proteins to the assembly site, genome packaging, as well as budding and release of virions.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:transport, late stages, assembly, budding, influenza virus
Language:English
Date:1 September 2016
Deposited On:23 Jan 2017 15:15
Last Modified:02 Feb 2018 11:41
Publisher:Society for General Microbiology
ISSN:0022-1317
OA Status:Closed
Publisher DOI:https://doi.org/10.1099/jgv.0.000562
PubMed ID:27449792

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