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Hydroxyapatite biomineralization on functionalized silicone nanofilaments


Saddiqi, Naeem-ul-Hasan; Patra, Debabrata; Seeger, Stefan (2017). Hydroxyapatite biomineralization on functionalized silicone nanofilaments. Colloid and Interface Science Communications, 16:1-5.

Abstract

In pursuit of designing novel biocompatible scaffold for hydroxyapatite (HA) growth, silicone nanofilaments coated surfaces have been investigated. High surface area of these 1-D nanofilaments offers large density of nucleation sites for biomineralization. The study shows that the amine and carboxylic acid functionalized SNFs enhance mineralization of HA particles whereas monolayer modified glass substrate did not show HA nucleation during the same period of time. Further investigation demonstrated the growth kinetics of HA particles and revealed that a dense and uniform coating of HA could be achieved after 7 days of immersion in simulated body fluid (SBF). This fast and facile approach could open up a new avenue for bone mineralization.

Abstract

In pursuit of designing novel biocompatible scaffold for hydroxyapatite (HA) growth, silicone nanofilaments coated surfaces have been investigated. High surface area of these 1-D nanofilaments offers large density of nucleation sites for biomineralization. The study shows that the amine and carboxylic acid functionalized SNFs enhance mineralization of HA particles whereas monolayer modified glass substrate did not show HA nucleation during the same period of time. Further investigation demonstrated the growth kinetics of HA particles and revealed that a dense and uniform coating of HA could be achieved after 7 days of immersion in simulated body fluid (SBF). This fast and facile approach could open up a new avenue for bone mineralization.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2017
Deposited On:25 Jan 2017 09:42
Last Modified:25 Jan 2017 09:42
Publisher:Elsevier
ISSN:2215-0382
Publisher DOI:https://doi.org/10.1016/j.colcom.2016.12.002

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