Header

UZH-Logo

Maintenance Infos

Probing the germline-dependence of non-genetic inheritance using artificial insemination in mice


Bohacek, Johannes; von Werdt, Sarah; Mansuy, Isabelle M (2016). Probing the germline-dependence of non-genetic inheritance using artificial insemination in mice. Environmental Epigenetics, 2(1):15-25.

Abstract

We developed a simple, noninvasive artificial insemination technique to study epigenetic germline inheritance in mice. This technique avoids interfering factors introduced by superovulation, surgery, in vitro culture or mating that can confound the transmission of acquired epigenetic information through the germline. Using a stress model, we demonstrate that our method is suited to test the causal involvement of the male germline in transmitting acquired information from father to offspring.

Abstract

We developed a simple, noninvasive artificial insemination technique to study epigenetic germline inheritance in mice. This technique avoids interfering factors introduced by superovulation, surgery, in vitro culture or mating that can confound the transmission of acquired epigenetic information through the germline. Using a stress model, we demonstrate that our method is suited to test the causal involvement of the male germline in transmitting acquired information from father to offspring.

Statistics

Altmetrics

Downloads

12 downloads since deposited on 25 Jan 2017
12 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2016
Deposited On:25 Jan 2017 09:31
Last Modified:25 Jan 2017 09:31
Publisher:Oxford University Press
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/eep/dvv015

Download

Download PDF  'Probing the germline-dependence of non-genetic inheritance using artificial insemination in mice'.
Preview
Content: Published Version
Filetype: PDF
Size: 827kB
View at publisher
Licence: Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)