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Molecular, cellular and pharmaceutical aspects of synthetic hydroxyapatite bone substitutes for oral and maxillofacial grafting


Goetz, Werner; Papageorgiou, Spyridon N (2017). Molecular, cellular and pharmaceutical aspects of synthetic hydroxyapatite bone substitutes for oral and maxillofacial grafting. Current Pharmaceutical Biotechnology, 18(1):95-106.

Abstract

Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

Abstract

Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Orthodontics and Pediatric Dentistry
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2017
Deposited On:01 Feb 2017 15:21
Last Modified:08 Dec 2017 22:52
Publisher:Bentham Science Publishers Ltd.
ISSN:1389-2010
Publisher DOI:https://doi.org/10.2174/1389201017666161202103218
PubMed ID:27915980

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