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Life history linked to immune investment in developing amphibians


Woodhams, Douglas C; Bell, Sara C; Bigler, Laurent; Caprioli, Richard M; Chaurand, Pierre; Lam, Brianna A; Reinert, Laura K; Stalder, Urs; Vazquez, Victoria M; Schliep, Klaus; Hertz, Andreas; Rollins-Smith, Louise A (2016). Life history linked to immune investment in developing amphibians. Conservation Physiology, 4(1):cow025.

Abstract

The broad diversity of amphibian developmental strategies has been shaped, in part, by pathogen pressure, yet trade-offs between the rate of larval development and immune investment remain poorly understood. The expression of antimicrobial peptides (AMPs) in skin secretions is a crucial defense against emerging amphibian pathogens and can also indirectly affect host defense by influencing the composition of skin microbiota. We examined the constitutive or induced expression of AMPs in 17 species at multiple life-history stages. We found that AMP defenses in tadpoles of species with short larval periods (fast pace of life) were reduced in comparison with species that overwinter as tadpoles and grow to a large size. A complete set of defensive peptides emerged soon after metamorphosis. These findings support the hypothesis that species with a slow pace of life invest energy in AMP production to resist potential pathogens encountered during the long larval period, whereas species with a fast pace of life trade this investment in defense for more rapid growth and development.

Abstract

The broad diversity of amphibian developmental strategies has been shaped, in part, by pathogen pressure, yet trade-offs between the rate of larval development and immune investment remain poorly understood. The expression of antimicrobial peptides (AMPs) in skin secretions is a crucial defense against emerging amphibian pathogens and can also indirectly affect host defense by influencing the composition of skin microbiota. We examined the constitutive or induced expression of AMPs in 17 species at multiple life-history stages. We found that AMP defenses in tadpoles of species with short larval periods (fast pace of life) were reduced in comparison with species that overwinter as tadpoles and grow to a large size. A complete set of defensive peptides emerged soon after metamorphosis. These findings support the hypothesis that species with a slow pace of life invest energy in AMP production to resist potential pathogens encountered during the long larval period, whereas species with a fast pace of life trade this investment in defense for more rapid growth and development.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2016
Deposited On:07 Feb 2017 11:44
Last Modified:18 Apr 2018 11:48
Publisher:Oxford University Press
ISSN:2051-1434
Funders:National Heart, Lung, and Blood Institute’s Immunology of Blood and Vascular Systems Training, Claraz Foundation, Swiss National Science Foundation, United States National Science Foundation, Integrated Research Challenges in Environmental Biology
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/conphys/cow025
PubMed ID:27928507
Project Information:
  • : Funder
  • : Grant ID
  • : Project TitleNational Heart, Lung, and Blood Institute’s Immunology of Blood and Vascular Systems Training
  • : Funder
  • : Grant ID
  • : Project TitleClaraz Foundation
  • : FunderSNSF
  • : Grant ID
  • : Project TitleSwiss National Science Foundation
  • : Funder
  • : Grant ID
  • : Project TitleUnited States National Science Foundation
  • : Funder
  • : Grant ID
  • : Project TitleIntegrated Research Challenges in Environmental Biology

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