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Results of the fifth scientific workshop of the ECCO [II]: clinical aspects of perianal fistulising crohn's disease-the unmet needs


Gecse, Krisztina B; Sebastian, Shaji; de Hertogh, Gert; Yassin, Nuha A; Kotze, Paulo G; Reinisch, Walter; Spinelli, Antonino; Koutroubakis, Ioannis E; Katsanos, Konstantinos H; Hart, Ailsa; van den Brink, Gijs R; Rogler, Gerhard; Bemelman, Willem A (2016). Results of the fifth scientific workshop of the ECCO [II]: clinical aspects of perianal fistulising crohn's disease-the unmet needs. Journal of Crohn's & colitis, 10(7):758-765.

Abstract

BACKGROUND AND AIMS Perianal fistulas affect up to one-third of Crohn's patients during the course of their disease. Despite the considerable disease burden, current treatment options remain unsatisfactory. The Fifth Scientific Workshop [SWS5] of the European Crohn's and Colitis Organisation [ECCO] focused on the pathophysiology and clinical impact of fistulas in the disease course of patients with Crohn's disease [CD].
METHODS The ECCO SWS5 Working Group on clinical aspects of perianal fistulising Crohn's disease [pCD] consisted of 13 participants, gastroenterologists, colorectal surgeons, and a histopathologist, with expertise in the field of inflammatory bowel diseases. A systematic review of literature was performed.
RESULTS Four main areas of interest were identified: natural history of pCD, morphological description of fistula tracts, outcome measures [including clinical and patient-reported outcome measures, as well as magnetic resonance imaging] and randomised controlled trials on pCD.
CONCLUSIONS The treatment of perianal fistulising Crohn's disease remains a multidisciplinary challenge. To optimise management, a reliable classification and proper trial endpoints are needed. This could lead to standardised diagnosis, treatment, and follow-up of Crohn's perianal fistulas and the execution of well-designed trials that provide clear answers. The prevalence and the natural history of pCD need further evaluation.

Abstract

BACKGROUND AND AIMS Perianal fistulas affect up to one-third of Crohn's patients during the course of their disease. Despite the considerable disease burden, current treatment options remain unsatisfactory. The Fifth Scientific Workshop [SWS5] of the European Crohn's and Colitis Organisation [ECCO] focused on the pathophysiology and clinical impact of fistulas in the disease course of patients with Crohn's disease [CD].
METHODS The ECCO SWS5 Working Group on clinical aspects of perianal fistulising Crohn's disease [pCD] consisted of 13 participants, gastroenterologists, colorectal surgeons, and a histopathologist, with expertise in the field of inflammatory bowel diseases. A systematic review of literature was performed.
RESULTS Four main areas of interest were identified: natural history of pCD, morphological description of fistula tracts, outcome measures [including clinical and patient-reported outcome measures, as well as magnetic resonance imaging] and randomised controlled trials on pCD.
CONCLUSIONS The treatment of perianal fistulising Crohn's disease remains a multidisciplinary challenge. To optimise management, a reliable classification and proper trial endpoints are needed. This could lead to standardised diagnosis, treatment, and follow-up of Crohn's perianal fistulas and the execution of well-designed trials that provide clear answers. The prevalence and the natural history of pCD need further evaluation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:July 2016
Deposited On:13 Feb 2017 15:10
Last Modified:19 Feb 2017 07:56
Publisher:Oxford University Press
ISSN:1873-9946
Publisher DOI:https://doi.org/10.1093/ecco-jcc/jjw039
PubMed ID:26826183

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