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Synthesis and Molecular Structure of 99Tc Corroles


Einrem, Rune F; Braband, Henrik; Fox, Thomas; Vazquez-Lima, Hugo; Alberto, Roger; Ghosh, Abhik (2016). Synthesis and Molecular Structure of 99Tc Corroles. Chemistry - A European Journal, 22(52):18747-18751.

Abstract

The first 99Tc corroles have been synthesized and fully characterized. A single-crystal X-ray structure of a 99TcO triarylcorrole revealed nearly identical geometry parameters as the corresponding ReO structure. A significant spectral shift between the Soret maxima of TcO (410–413 nm) and ReO (438–441 nm) corroles was observed and, based on two-component spin–orbit ZORA TDDFT calculations, ascribed to relativistic effects in the Re case. The syntheses reported herein potentially pave the way toward 99mTc-porphyrinoid-based radiopharmaceuticals.

Abstract

The first 99Tc corroles have been synthesized and fully characterized. A single-crystal X-ray structure of a 99TcO triarylcorrole revealed nearly identical geometry parameters as the corresponding ReO structure. A significant spectral shift between the Soret maxima of TcO (410–413 nm) and ReO (438–441 nm) corroles was observed and, based on two-component spin–orbit ZORA TDDFT calculations, ascribed to relativistic effects in the Re case. The syntheses reported herein potentially pave the way toward 99mTc-porphyrinoid-based radiopharmaceuticals.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2016
Deposited On:09 Feb 2017 12:48
Last Modified:09 Feb 2017 12:49
Publisher:Wiley-VCH Verlag
ISSN:0947-6539
Funders:Research Council of Norway (FRINATEK grant no. 231086, A.G.), SNF (project no. 200021_156256, H.B., R.A.).
Publisher DOI:https://doi.org/10.1002/chem.201605015

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