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A fluorescent surrogate of thymidine in duplex DNA


Mata, Guillaume; Schmidt, Olivia P; Luedtke, Nathan W (2016). A fluorescent surrogate of thymidine in duplex DNA. Chemical Communications, 52(25):4718-4721.

Abstract

DMAT is a new fluorescent thymidine mimic composed of 2′-deoxyuridine fused to dimethylaniline. DMAT exhibits the same pKa and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

Abstract

DMAT is a new fluorescent thymidine mimic composed of 2′-deoxyuridine fused to dimethylaniline. DMAT exhibits the same pKa and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2016
Deposited On:09 Feb 2017 15:33
Last Modified:02 Feb 2018 12:13
Publisher:Royal Society of Chemistry
ISSN:1359-7345
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1039/c5cc09552b

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