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Non-parametric intravoxel incoherent motion analysis of the thyroid gland


Becker, Anton S; Wurnig, Moritz C; Finkenstaedt, Tim; Boss, Andreas (2017). Non-parametric intravoxel incoherent motion analysis of the thyroid gland. Heliyon, 3(1):e00239.

Abstract

PURPOSE To implement a protocol for intravoxel incoherent motion (IVIM) of the thyroid, to determine base parameters in healthy volunteers, and to provide preliminary experience on clinical applicability in one patient.
MATERIALS AND METHODS Eight healthy volunteers underwent 3T MRI using a diffusion weighted echo-planar imaging sequence with 12 different b-values between 0-800 s/mm(2). The IVIM parameters diffusion coefficient D, pseudo-diffusion coefficient D*, perfusion fraction Fp, and the optimal b-values thresholds were calculated for each thyroid lobe, muscle tissue and the cerebrospinal fluid (CSF) using a non-parametric multi-step algorithm and compared with a Student's t-test. A p-value <0.05 was considered significant.
RESULTS Mean values for healthy thyroid tissue were: D 1.01 ± 0.13 × 10(-3) mm(2)/s, D* 71.0 ± 52.5 × 10(-3) mm(2)/s and Fp 17.1 ± 4.2%; for muscle: D 0.50 ± 0.21 × 10(-3) mm(2)/s, D* 58.3 ± 99.2 × 10(-3) mm(2)/s and Fp 26.5 ± 9.3%; and for CSF D 2.18 ± 0.93 × 10(-3) mm(2)/s, D* 99.2 ± 41.2 × 10(-3) mm(2)/s and Fp 74.6 ± 12.7%. The optimal b-value threshold separating diffusion and perfusion effects in thyroid ranged between 0-70 s/mm(2). Healthy thyroid tissue showed similar Fp compared to muscle, both lower than CSF.
CONCLUSIONS The proposed IVIM protocol provides surrogate markers on cellular diffusion restriction and perfusion; thereby providing a more comprehensive description of tissue properties compared to conventional DWI.

Abstract

PURPOSE To implement a protocol for intravoxel incoherent motion (IVIM) of the thyroid, to determine base parameters in healthy volunteers, and to provide preliminary experience on clinical applicability in one patient.
MATERIALS AND METHODS Eight healthy volunteers underwent 3T MRI using a diffusion weighted echo-planar imaging sequence with 12 different b-values between 0-800 s/mm(2). The IVIM parameters diffusion coefficient D, pseudo-diffusion coefficient D*, perfusion fraction Fp, and the optimal b-values thresholds were calculated for each thyroid lobe, muscle tissue and the cerebrospinal fluid (CSF) using a non-parametric multi-step algorithm and compared with a Student's t-test. A p-value <0.05 was considered significant.
RESULTS Mean values for healthy thyroid tissue were: D 1.01 ± 0.13 × 10(-3) mm(2)/s, D* 71.0 ± 52.5 × 10(-3) mm(2)/s and Fp 17.1 ± 4.2%; for muscle: D 0.50 ± 0.21 × 10(-3) mm(2)/s, D* 58.3 ± 99.2 × 10(-3) mm(2)/s and Fp 26.5 ± 9.3%; and for CSF D 2.18 ± 0.93 × 10(-3) mm(2)/s, D* 99.2 ± 41.2 × 10(-3) mm(2)/s and Fp 74.6 ± 12.7%. The optimal b-value threshold separating diffusion and perfusion effects in thyroid ranged between 0-70 s/mm(2). Healthy thyroid tissue showed similar Fp compared to muscle, both lower than CSF.
CONCLUSIONS The proposed IVIM protocol provides surrogate markers on cellular diffusion restriction and perfusion; thereby providing a more comprehensive description of tissue properties compared to conventional DWI.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:January 2017
Deposited On:16 Feb 2017 09:46
Last Modified:06 Aug 2017 08:59
Publisher:Elsevier
ISSN:2405-8440
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.heliyon.2017.e00239
PubMed ID:28180186

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