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Thermodilution-determined Internal Jugular Venous Flow


Rasmussen, Peter; Widmer, Mario; Hilty, Matthias P; Hug, Mike; Sørensen, Henrik; Ogoh, Shigehiko; Sato, Kohei; Secher, Niels H; Maggiorini, Marco; Lundby, Carsten (2017). Thermodilution-determined Internal Jugular Venous Flow. Medicine and Science in Sports and Exercise, 49(4):661-668.

Abstract

PURPOSE: Cerebral blood flow (CBF) increases ~20% during whole body exercise although a Kety-Schmidt-determined CBF is reported to remain stable; a discrepancy that could reflect evaluation of arterial vs. internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained.
METHODS: Introducing retrograde thermodilution, IJV flow was measured in 8 healthy humans at supine and upright rest and during exercise in normoxia and hypoxia with results compared to changes in ultrasound-derived IJV flow and middle cerebral artery mean velocity (MCA Vmean).
RESULTS: Thermodilution determined IJV flow was in reasonable agreement with values established in a phantom (R=0.59, p<0.0001) and correlated to the ultrasound-derived IJV flow (n=7; Kendall's tau, 0.28, p= 0.036). When subjects stood up, IJV blood flow decreased by 9±13 (mean±SD)% (219±57 to 191±73 ml·min, p<0.0001) and the influence of body position was maintained during exercise (p<0.0001). Exercise increased both IJV flow and MCA Vmean (p=0.019 and p=0.012, respectively) and the two responses were similar (p=0.50). During hypoxia, however, only MCA Vmean responded with a further increase (p<0.0001).
CONCLUSION: As determined by retrograde thermodilution, IJV flow seems little sensitive to hypoxia, but does demonstrate the about 15% reduction in CBF when humans are upright and, provided that body position is maintained, also the increase in CBF during whole body exercise.

Abstract

PURPOSE: Cerebral blood flow (CBF) increases ~20% during whole body exercise although a Kety-Schmidt-determined CBF is reported to remain stable; a discrepancy that could reflect evaluation of arterial vs. internal jugular venous (IJV) flow and/or that CBF is influenced by posture. Here we test the hypothesis that IJV flow, as determined by retrograde thermodilution increases during exercise when body position is maintained.
METHODS: Introducing retrograde thermodilution, IJV flow was measured in 8 healthy humans at supine and upright rest and during exercise in normoxia and hypoxia with results compared to changes in ultrasound-derived IJV flow and middle cerebral artery mean velocity (MCA Vmean).
RESULTS: Thermodilution determined IJV flow was in reasonable agreement with values established in a phantom (R=0.59, p<0.0001) and correlated to the ultrasound-derived IJV flow (n=7; Kendall's tau, 0.28, p= 0.036). When subjects stood up, IJV blood flow decreased by 9±13 (mean±SD)% (219±57 to 191±73 ml·min, p<0.0001) and the influence of body position was maintained during exercise (p<0.0001). Exercise increased both IJV flow and MCA Vmean (p=0.019 and p=0.012, respectively) and the two responses were similar (p=0.50). During hypoxia, however, only MCA Vmean responded with a further increase (p<0.0001).
CONCLUSION: As determined by retrograde thermodilution, IJV flow seems little sensitive to hypoxia, but does demonstrate the about 15% reduction in CBF when humans are upright and, provided that body position is maintained, also the increase in CBF during whole body exercise.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2017
Deposited On:15 Mar 2017 11:18
Last Modified:07 Apr 2017 01:04
Publisher:Lippincott Williams & Wilkins
ISSN:0195-9131
Additional Information:This is a non-final version of an article published in final form in Med Sci Sports Exerc. 2016 Nov 17 PMID: 27861273, DOI: https://doi.org/10.1249/MSS.0000000000001143
Publisher DOI:https://doi.org/10.1249/MSS.0000000000001143
PubMed ID:27861273

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