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Metastatic melanoma moves on: translational science in the era of personalized medicine


Levesque, Mitchell P; Cheng, Phil F; Raaijmakers, Marieke I G; Saltari, Annalisa; Dummer, Reinhard (2017). Metastatic melanoma moves on: translational science in the era of personalized medicine. Cancer Metastasis Reviews, 36(1):7-21.

Abstract

Progress in understanding and treating metastatic melanoma is the result of decades of basic and translational research as well as the development of better in vitro tools for modeling the disease. Here, we review the latest therapeutic options for metastatic melanoma and the known genetic and non-genetic mechanisms of resistance to these therapies, as well as the in vitro toolbox that has provided the greatest insights into melanoma progression. These include next-generation sequencing technologies and more complex 2D and 3D cell culture models to functionally test the data generated by genomics approaches. The combination of hypothesis generating and hypothesis testing paradigms reviewed here will be the foundation for the next phase of metastatic melanoma therapies in the coming years.

Abstract

Progress in understanding and treating metastatic melanoma is the result of decades of basic and translational research as well as the development of better in vitro tools for modeling the disease. Here, we review the latest therapeutic options for metastatic melanoma and the known genetic and non-genetic mechanisms of resistance to these therapies, as well as the in vitro toolbox that has provided the greatest insights into melanoma progression. These include next-generation sequencing technologies and more complex 2D and 3D cell culture models to functionally test the data generated by genomics approaches. The combination of hypothesis generating and hypothesis testing paradigms reviewed here will be the foundation for the next phase of metastatic melanoma therapies in the coming years.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Melanoma; 3D culture; Translational research; Bioengineered skin; Skin reconstructs; Melanoma treatment
Language:English
Date:2017
Deposited On:31 Mar 2017 06:08
Last Modified:07 Apr 2017 01:05
Publisher:Springer
ISSN:0167-7659
Publisher DOI:https://doi.org/10.1007/s10555-017-9658-0
PubMed ID:28321632

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