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Cutting edge: competition for APC by CTLs of different specificities is not functionally important during induction of antiviral responses


Probst, Hans Christian; Dumrese, Tilman; van den Broek, Maries F (2002). Cutting edge: competition for APC by CTLs of different specificities is not functionally important during induction of antiviral responses. Journal of Immunology, 168(11):5387-5391.

Abstract

The hypothesis that T cell competition for access to APC influences priming of CTL responses is a controversial issue. A recent study using OVA as a model Ag supports this hypothesis and received considerable attention. However, using a comparable approach, we reached a different conclusion. We analyzed whether TCR transgenic T cells specific for lymphocytic choriomeningitis virus gp33-41/D(b) could inhibit the priming of endogenous responses against gp33-41 and against two other lymphocytic choriomeningitis virus glycoprotein-derived CTL epitopes. After priming with different stimuli, gp33-41/D(b)-specific TCR transgenic T cells reduced the endogenous gp33-41/D(b) response in a dose-dependent way, but all other endogenous responses were unaffected. Even when >10(6) TCR transgenic cells were combined with weak priming, no reduction of responses other than of those specific for gp33-41/D(b) was observed. Thus, competition for APC by CTLs of different specificities is not of functional relevance in antiviral immune responses.

Abstract

The hypothesis that T cell competition for access to APC influences priming of CTL responses is a controversial issue. A recent study using OVA as a model Ag supports this hypothesis and received considerable attention. However, using a comparable approach, we reached a different conclusion. We analyzed whether TCR transgenic T cells specific for lymphocytic choriomeningitis virus gp33-41/D(b) could inhibit the priming of endogenous responses against gp33-41 and against two other lymphocytic choriomeningitis virus glycoprotein-derived CTL epitopes. After priming with different stimuli, gp33-41/D(b)-specific TCR transgenic T cells reduced the endogenous gp33-41/D(b) response in a dose-dependent way, but all other endogenous responses were unaffected. Even when >10(6) TCR transgenic cells were combined with weak priming, no reduction of responses other than of those specific for gp33-41/D(b) was observed. Thus, competition for APC by CTLs of different specificities is not of functional relevance in antiviral immune responses.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 June 2002
Deposited On:09 Feb 2018 07:44
Last Modified:19 Feb 2018 21:47
Publisher:American Association of Immunologists
ISSN:0022-1767
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.4049/jimmunol.168.11.5387
PubMed ID:12023329

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