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DC infection promotes antiviral CTL priming: the 'Winkelried' strategy


Freigang, Stefan; Probst, Hans Christian; van den Broek, Maries (2005). DC infection promotes antiviral CTL priming: the 'Winkelried' strategy. Trends in Immunology, 26(1):13-18.

Abstract

In addition to the presentation of antigens generated by endogenous neosynthesis, dendritic cells (DCs) can cross-present antigen taken up from the extracellular milieu. However, the relative contribution of these pathways to the priming of antiviral cytotoxic T-lymphocyte (CTL) responses is still elusive. Here, we propose that - in analogy to the sacrifice of the Swiss hero Arnold von Winkelried, who deliberately took into his body the spears of the enemy for the sake of victory - the unique susceptibility of DCs to become infected by a wide range of viruses, even in the absence of the specific virus receptor, serves as a strategy to prime antiviral CTL responses. This could explain CTL priming against viruses that exclusively replicate in peripheral organs.

Abstract

In addition to the presentation of antigens generated by endogenous neosynthesis, dendritic cells (DCs) can cross-present antigen taken up from the extracellular milieu. However, the relative contribution of these pathways to the priming of antiviral cytotoxic T-lymphocyte (CTL) responses is still elusive. Here, we propose that - in analogy to the sacrifice of the Swiss hero Arnold von Winkelried, who deliberately took into his body the spears of the enemy for the sake of victory - the unique susceptibility of DCs to become infected by a wide range of viruses, even in the absence of the specific virus receptor, serves as a strategy to prime antiviral CTL responses. This could explain CTL priming against viruses that exclusively replicate in peripheral organs.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:January 2005
Deposited On:08 Feb 2018 15:35
Last Modified:19 Feb 2018 20:15
Publisher:Elsevier
ISSN:1471-4906
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.it.2004.11.013
PubMed ID:15629404

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