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Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?


Huber, Eveline; Lachappelle, Patrice; Sutter, Reto; Curt, Armin; Freund, Patrick (2017). Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury? Annals of Neurology, 81(5):740-748.

Abstract

T2-weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At one month post-injury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at one month post-injury were associated with neurological and functional recovery at 1 year follow-up. Neuroimaging biomarkers of lesion area and midsagittal tissue bridges are potential outcome predictors and patient stratifiers in both subacute and chronic clinical trials. This article is protected by copyright. All rights reserved.

Abstract

T2-weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At one month post-injury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at one month post-injury were associated with neurological and functional recovery at 1 year follow-up. Neuroimaging biomarkers of lesion area and midsagittal tissue bridges are potential outcome predictors and patient stratifiers in both subacute and chronic clinical trials. This article is protected by copyright. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:10 April 2017
Deposited On:03 May 2017 15:17
Last Modified:24 May 2017 01:03
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0364-5134
Publisher DOI:https://doi.org/10.1002/ana.24932
PubMed ID:28393423

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