Header

UZH-Logo

Maintenance Infos

15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia


Ulfarsson, M O; Walters, G B; et al; Brandeis, D (2017). 15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia. Translational Psychiatry, 7(4):e1109.

Abstract

Several copy number variants have been associated with neuropsychiatric disorders and these variants have been shown to also influence cognitive abilities in carriers unaffected by psychiatric disorders. Previously, we associated the 15q11.2(BP1-BP2) deletion with specific learning disabilities and a larger corpus callosum. Here we investigate, in a much larger sample, the effect of the 15q11.2(BP1-BP2) deletion on cognitive, structural and functional correlates of dyslexia and dyscalculia. We report that the deletion confers greatest risk of the combined phenotype of dyslexia and dyscalculia. We also show that the deletion associates with a smaller left fusiform gyrus. Moreover, tailored functional magnetic resonance imaging experiments using phonological lexical decision and multiplication verification tasks demonstrate altered activation in the left fusiform and the left angular gyri in carriers. Thus, by using convergent evidence from neuropsychological testing, and structural and functional neuroimaging, we show that the 15q11.2(BP1-BP2) deletion affects cognitive, structural and functional correlates of both dyslexia and dyscalculia.

Abstract

Several copy number variants have been associated with neuropsychiatric disorders and these variants have been shown to also influence cognitive abilities in carriers unaffected by psychiatric disorders. Previously, we associated the 15q11.2(BP1-BP2) deletion with specific learning disabilities and a larger corpus callosum. Here we investigate, in a much larger sample, the effect of the 15q11.2(BP1-BP2) deletion on cognitive, structural and functional correlates of dyslexia and dyscalculia. We report that the deletion confers greatest risk of the combined phenotype of dyslexia and dyscalculia. We also show that the deletion associates with a smaller left fusiform gyrus. Moreover, tailored functional magnetic resonance imaging experiments using phonological lexical decision and multiplication verification tasks demonstrate altered activation in the left fusiform and the left angular gyri in carriers. Thus, by using convergent evidence from neuropsychological testing, and structural and functional neuroimaging, we show that the 15q11.2(BP1-BP2) deletion affects cognitive, structural and functional correlates of both dyslexia and dyscalculia.

Statistics

Citations

Altmetrics

Downloads

8 downloads since deposited on 13 Jun 2017
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:25 April 2017
Deposited On:13 Jun 2017 12:40
Last Modified:06 Aug 2017 01:49
Publisher:Nature Publishing Group
ISSN:2158-3188
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/tp.2017.77
PubMed ID:28440815

Download

Preview Icon on Download
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 926kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)