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Enhanced quantitative susceptibility mapping (QSM) using real-time field control


Özbay, Pinar Senay; Duerst, Yolanda; Wilm, Bertram Jakob; Pruessmann, Klaas Paul; Nanz, Daniel (2018). Enhanced quantitative susceptibility mapping (QSM) using real-time field control. Magnetic Resonance in Medicine, 79(2):770-778.

Abstract

PURPOSE: To assess the potential of a real-time field-control (FC) system for mitigating effects of spatiotemporal field fluctuations in quantitative susceptibility mapping (QSM) at 7 T.
METHODS: Magnitude, phase, and QSM images of phantoms and healthy volunteers were acquired under standard conditions and under induced field perturbation (FP) (phantoms: periodic water-bottle displacement; volunteers: deep breathing and forearm movement) with and without FC, which continuously detects and minimizes magnetic-field variations.
RESULTS: Field control successfully eliminated FP-induced impairment of phantom image quality and deviations from a linear susceptibility increase for increasing gadolinium concentration in a Gd dilution series (y = 320x - 0.60, R(2)  = 0.93 for the scan with FP and FC versus y = 259x - 0.54, R(2)  = 0.78 for the scan with FP and no FC (slope literature value: 326 ppm L/mol)). Similarly, in volunteers, FC allowed a recovery of a FP-induced loss of identifiable brain structures and reduced the relative change of mean susceptibilities and standard deviations (93 ± 53% to 34 ± 46%) in all regions of interests with respect to the reference scan.
CONCLUSIONS: Real-time FC improved the delineation of brain structures and the match of susceptibility values with reference values obtained without FP. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

Abstract

PURPOSE: To assess the potential of a real-time field-control (FC) system for mitigating effects of spatiotemporal field fluctuations in quantitative susceptibility mapping (QSM) at 7 T.
METHODS: Magnitude, phase, and QSM images of phantoms and healthy volunteers were acquired under standard conditions and under induced field perturbation (FP) (phantoms: periodic water-bottle displacement; volunteers: deep breathing and forearm movement) with and without FC, which continuously detects and minimizes magnetic-field variations.
RESULTS: Field control successfully eliminated FP-induced impairment of phantom image quality and deviations from a linear susceptibility increase for increasing gadolinium concentration in a Gd dilution series (y = 320x - 0.60, R(2)  = 0.93 for the scan with FP and FC versus y = 259x - 0.54, R(2)  = 0.78 for the scan with FP and no FC (slope literature value: 326 ppm L/mol)). Similarly, in volunteers, FC allowed a recovery of a FP-induced loss of identifiable brain structures and reduced the relative change of mean susceptibilities and standard deviations (93 ± 53% to 34 ± 46%) in all regions of interests with respect to the reference scan.
CONCLUSIONS: Real-time FC improved the delineation of brain structures and the match of susceptibility values with reference values obtained without FP. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:February 2018
Deposited On:23 Jun 2017 09:52
Last Modified:20 Feb 2018 08:52
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0740-3194
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/mrm.26735
PubMed ID:28556247

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