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Activity of synthetic peptides against Chlamydia


Abstract

The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from 8 different species tested by ≥50% at 10 μg.ml-1. Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus and C. avium even at 80 μg.ml-1. These data suggest that clavanin MO could be a promising compound in the prevention and treatment of chlamydial infections.

Abstract

The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from 8 different species tested by ≥50% at 10 μg.ml-1. Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus and C. avium even at 80 μg.ml-1. These data suggest that clavanin MO could be a promising compound in the prevention and treatment of chlamydial infections.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Chlamydia; antimicrobial; immunofluorescence; peptides
Language:English
Date:2017
Deposited On:06 Jul 2017 09:22
Last Modified:09 Dec 2017 01:31
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0006-3525
Additional Information:This is the peer reviewed version of the following article :Activity of synthetic peptides against Chlamydia which has been published in final form at Biopolymers. 2017 May 27, DOI 10.1002/bip.23032. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms).
Publisher DOI:https://doi.org/10.1002/bip.23032
PubMed ID:28555934

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