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Unravelling HIV-1 latency, one cell at a time


Kok, Yik Lim; Ciuffi, Angela; Metzner, Karin J (2017). Unravelling HIV-1 latency, one cell at a time. Trends in Microbiology, 25(11):932-941.

Abstract

A single virus is capable of infecting and replicating in a single cell. Recent advances across single-cell omics technologies - genomics, epigenomics, transcriptomics, epitranscriptomics, proteomics, and metabolomics - will offer unprecedented opportunities to gain more insights into the various aspects of the life cycle of viruses and their impact on the host cell. Here, using the human immunodeficiency virus type 1 (HIV-1) as an example, we summarize the current knowledge and the future potential of single-cell omics in the investigation of an important aspect of the life cycle of HIV-1 that represents a major hurdle in achieving viral eradication, HIV-1 latency.

Abstract

A single virus is capable of infecting and replicating in a single cell. Recent advances across single-cell omics technologies - genomics, epigenomics, transcriptomics, epitranscriptomics, proteomics, and metabolomics - will offer unprecedented opportunities to gain more insights into the various aspects of the life cycle of viruses and their impact on the host cell. Here, using the human immunodeficiency virus type 1 (HIV-1) as an example, we summarize the current knowledge and the future potential of single-cell omics in the investigation of an important aspect of the life cycle of HIV-1 that represents a major hurdle in achieving viral eradication, HIV-1 latency.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:HIV-1 integration sites; human immunodeficiency virus type 1; single-cell omics; viral latency
Language:English
Date:28 June 2017
Deposited On:04 Aug 2017 15:24
Last Modified:19 Feb 2018 08:19
Publisher:Elsevier
ISSN:0966-842X
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.tim.2017.06.002
PubMed ID:28668335

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