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Macrophage heterogeneity and energy metabolism


Verdeguer, Francisco; Aouadi, Myriam (2017). Macrophage heterogeneity and energy metabolism. Experimental Cell Research:Epub ahead of print.

Abstract

Macrophages are versatile and multifunctional cell types present in most vertebrate tissues. They are the first line of defense against pathogens through phagocytosis of microbial infections, particles and dead cells. Macrophages harbor additional functions besides immune protection by participating in essential homeostatic and tissue development functions. The immune response requires a concomitant and coordinated regulation of the energetic metabolism. In this review, we will discuss how macrophages influence metabolic tissues and in turn how metabolic pathways, particularly glucose and lipid metabolism, affect macrophage phenotypes.

Abstract

Macrophages are versatile and multifunctional cell types present in most vertebrate tissues. They are the first line of defense against pathogens through phagocytosis of microbial infections, particles and dead cells. Macrophages harbor additional functions besides immune protection by participating in essential homeostatic and tissue development functions. The immune response requires a concomitant and coordinated regulation of the energetic metabolism. In this review, we will discuss how macrophages influence metabolic tissues and in turn how metabolic pathways, particularly glucose and lipid metabolism, affect macrophage phenotypes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Diabetes; Insulin resistance; Macrophage polarization; Metabolism
Language:English
Date:21 March 2017
Deposited On:18 Aug 2017 15:56
Last Modified:19 Aug 2017 07:27
Publisher:Elsevier
ISSN:0014-4827
Publisher DOI:https://doi.org/10.1016/j.yexcr.2017.03.043
PubMed ID:28341447

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