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Structure elucidation of polyamine toxins in the venom of the spider larinioides folium


Eichenberger, Silvan; Bigler, Laurent; Bienz, Stefan (2007). Structure elucidation of polyamine toxins in the venom of the spider larinioides folium. CHIMIA International Journal for Chemistry, 61(4):161-164.

Abstract

The lyophilized venom of the spider Larinioides folium (Araneidae) was analyzed by high-performance liquid chromatography, coupled on-line to electrospray ionization mass spectrometry (HPLC-ESI-MS) and tandem mass spectrometry (HPLC-ESI-MS/MS), as well as UV-DAD analysis. In combination with amino acid analysis, high-resolution mass spectrometry and on-column H/D-exchange experiments, the structures of 41 new acylpolyamines contained in the complex venom of the spider L. folium were elucidated. Data interpretation in detail and the efficiency of this combined set of analytical method is exemplified by the structural elucidation of one of the toxins, namely of LF503a.

Abstract

The lyophilized venom of the spider Larinioides folium (Araneidae) was analyzed by high-performance liquid chromatography, coupled on-line to electrospray ionization mass spectrometry (HPLC-ESI-MS) and tandem mass spectrometry (HPLC-ESI-MS/MS), as well as UV-DAD analysis. In combination with amino acid analysis, high-resolution mass spectrometry and on-column H/D-exchange experiments, the structures of 41 new acylpolyamines contained in the complex venom of the spider L. folium were elucidated. Data interpretation in detail and the efficiency of this combined set of analytical method is exemplified by the structural elucidation of one of the toxins, namely of LF503a.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Uncontrolled Keywords:Liquid chromatography, Polyamine alkaloids, spider venom, structure elucidation, tandem mass spectrometry
Language:English
Date:April 2007
Deposited On:23 Aug 2017 16:08
Last Modified:23 Aug 2017 16:08
Publisher:Swiss Chemical Society
ISSN:0009-4293
Publisher DOI:https://doi.org/10.2533/chimia.2007.161

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