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Metal Ion-Promoted Conformational Changes of Oligonucleotides


Spingler, Bernhard (2012). Metal Ion-Promoted Conformational Changes of Oligonucleotides. In: Sigel, Astrid; Sigel, Helmut; Sigel, Roland K O. Interplay between Metal Ions and Nucleic Acids. Dordrecht: Springer, 103-118.

Abstract

The review will discuss the influence of metal ions on conformational changes of oligonucleotides. First, a short definition of the torsion angles is given, followed by a concise yet critical overview of the commonly applied experimental techniques. Finally, the possible role of metals upon the following conformational changes of oligonucleotides is discussed: (i) the denaturation of double-strands, (ii) the transition from B- to A-DNA, (iii) the transition from right- to left-handed DNA and RNA, (iv) the condensation, (v) and other conformational changes. We conclude with a summary and outlook.

Abstract

The review will discuss the influence of metal ions on conformational changes of oligonucleotides. First, a short definition of the torsion angles is given, followed by a concise yet critical overview of the commonly applied experimental techniques. Finally, the possible role of metals upon the following conformational changes of oligonucleotides is discussed: (i) the denaturation of double-strands, (ii) the transition from B- to A-DNA, (iii) the transition from right- to left-handed DNA and RNA, (iv) the condensation, (v) and other conformational changes. We conclude with a summary and outlook.

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Additional indexing

Item Type:Book Section, refereed, further contribution
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:January 2012
Deposited On:29 Aug 2017 13:12
Last Modified:17 Feb 2018 01:56
Publisher:Springer
Series Name:Metal Ions in Life Sciences
ISSN:1559-0836
ISBN:978-94-007-2171-5
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-94-007-2172-2_3

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