Header

UZH-Logo

Maintenance Infos

Cocaine Accumulation in Zebrafish Eyes Leads to Augmented Amplitudes in the Electroretinogram


Kirla, Krishna Tulasi; Niklaus, Stephanie; Kraemer, Thomas; Groh, Ksenia; Schirmer, Kristin; Neuhauss, Stephan (2017). Cocaine Accumulation in Zebrafish Eyes Leads to Augmented Amplitudes in the Electroretinogram. Matters:1-4.

Abstract

Zebrafish larvae exposed to cocaine accumulate cocaine in the eye. Here we used electroretinography (ERG) to assess the effect of accumulated cocaine on the outer retina function of zebrafish larval eyes. We found a statistically significant increase of the ERG responses at moderate to bright light levels, showing that the presence of cocaine increased retinal responses to light, especially in the bright light range. This increase may be linked to dopamine in the retina, since cocaine is known to increase effective dopamine concentrations in the nervous system.

Abstract

Zebrafish larvae exposed to cocaine accumulate cocaine in the eye. Here we used electroretinography (ERG) to assess the effect of accumulated cocaine on the outer retina function of zebrafish larval eyes. We found a statistically significant increase of the ERG responses at moderate to bright light levels, showing that the presence of cocaine increased retinal responses to light, especially in the bright light range. This increase may be linked to dopamine in the retina, since cocaine is known to increase effective dopamine concentrations in the nervous system.

Statistics

Altmetrics

Downloads

8 downloads since deposited on 05 Sep 2017
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:3 June 2017
Deposited On:05 Sep 2017 13:02
Last Modified:09 Dec 2017 02:10
Publisher:ScienceMatters AG
ISSN:2297-8240
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.19185/matters.201703000003

Download

Download PDF  'Cocaine Accumulation in Zebrafish Eyes Leads to Augmented Amplitudes in the Electroretinogram'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 949kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)