Header

UZH-Logo

Maintenance Infos

Novel hyperthermia applicator system allows adaptive treatment planning: preliminary clinical results in tumour-bearing animals


Dressel, S; Gosselin, M C; Capstick, M H; Carrasco, E; Weyland, M S; Scheidegger, Simon; Neufeld, Esra; Kuster, N; Bodis, S; Rohrer Bley, C (2017). Novel hyperthermia applicator system allows adaptive treatment planning: preliminary clinical results in tumour-bearing animals. Veterinary and Comparative Oncology:Epub ahead of print.

Abstract

Hyperthermia (HT) as an adjuvant to radiation therapy (RT) is a multimodality treatment method to enhance therapeutic efficacy in different tumours. High demands are placed on the hardware and treatment planning software to guarantee adequately planned and applied HT treatments. The aim of this prospective study was to determine the effectiveness and safety of the novel HT system in tumour-bearing dogs and cats in terms of local response and toxicity as well as to compare planned with actual achieved data during heating. A novel applicator with a flexible number of elements and integrated closed-loop temperature feedback control system, and a tool for patient-specific treatment planning were used in a combined thermoradiotherapy protocol. Good agreement between predictions from planning and clinical outcome was found in 7 of 8 cases. Effective HT treatments were planned and verified with the novel system and provided improved quality of life in all but 1 patient. This individualized treatment planning and controlled heat exposure allows adaptive, flexible and safe HT treatments in palliatively treated animal patients.

Abstract

Hyperthermia (HT) as an adjuvant to radiation therapy (RT) is a multimodality treatment method to enhance therapeutic efficacy in different tumours. High demands are placed on the hardware and treatment planning software to guarantee adequately planned and applied HT treatments. The aim of this prospective study was to determine the effectiveness and safety of the novel HT system in tumour-bearing dogs and cats in terms of local response and toxicity as well as to compare planned with actual achieved data during heating. A novel applicator with a flexible number of elements and integrated closed-loop temperature feedback control system, and a tool for patient-specific treatment planning were used in a combined thermoradiotherapy protocol. Good agreement between predictions from planning and clinical outcome was found in 7 of 8 cases. Effective HT treatments were planned and verified with the novel system and provided improved quality of life in all but 1 patient. This individualized treatment planning and controlled heat exposure allows adaptive, flexible and safe HT treatments in palliatively treated animal patients.

Statistics

Altmetrics

Downloads

0 downloads since deposited on 21 Sep 2017
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:adaptive treatment planning; cats; dogs; hyperthermia; radiation; tumour
Language:English
Date:11 September 2017
Deposited On:21 Sep 2017 13:13
Last Modified:21 Sep 2017 13:13
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1476-5810
Publisher DOI:https://doi.org/10.1111/vco.12340
PubMed ID:28892246

Download