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Specialized weaponry: how a type III-A CRISPR-cas system excels at combating phages


Niewoehner, Ole; Jinek, Martin (2017). Specialized weaponry: how a type III-A CRISPR-cas system excels at combating phages. Cell Host & Microbe, 22(3):258-259.

Abstract

CRISPR-Cas-mediated defense against phage invaders usually requires recognition of short sequences, termed protospacer-adjacent motifs (PAMs), in phage DNA. In this issue of Cell Host & Microbe, Pyenson et al. (2017) show that the lack of a PAM requirement in some CRISPR-Cas systems prevents interference evasion and facilitates phage extinction.

Abstract

CRISPR-Cas-mediated defense against phage invaders usually requires recognition of short sequences, termed protospacer-adjacent motifs (PAMs), in phage DNA. In this issue of Cell Host & Microbe, Pyenson et al. (2017) show that the lack of a PAM requirement in some CRISPR-Cas systems prevents interference evasion and facilitates phage extinction.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:13 September 2017
Deposited On:26 Sep 2017 14:51
Last Modified:09 Dec 2017 02:24
Publisher:Cell Press (Elsevier)
ISSN:1931-3128
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.chom.2017.08.019
PubMed ID:28910631

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