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Fracture healing and the underexposed role of extracellular vesicle-based crosstalk


Qiao, Zhi; Greven, Johannes; Horst, Klemens; Pfeifer, Roman; Kobbe, Philipp; Pape, Hans-Christoph; Hildebrand, Frank (2018). Fracture healing and the underexposed role of extracellular vesicle-based crosstalk. Shock, 49(5):486-496.

Abstract

The process of fracture healing is complex and requires an interaction of multiple organ systems. Cell-cell communication is known to be very important during this process. Extracellular vesicle (EVs) are small membranous vesicles generated from a variety of cells. Proteins, RNAs, small molecules and mitochondria DNA were found to be transported among cells through EVs. EV-based crosstalk represents a substantial cell-cell communication pattern, that can both interact with cells through molecular surfaces, and transfer molecules to cells. These interactions can assist in the synchronization of cellular functions among cells of the same kind, and coordinate the functions of different types of cells. After activation, platelets, neutrophils, macrophages, osteoblasts, osteoclasts, and mesenchymal stem cell (MSC) all secrete EVs, promoting the fracture healing process. Moreover, some studies have found evidence that EVs may be used for diagnosis and treatment of delayed fracture healing, and may be significantly involved in the pathophysiology of fracture healing disturbances. In this review, we summarize recent findings on: 1) EVs released by fracture healing-related cells, and 2) EV-mediated communications during fracture healing. We also highlight the potential applications of EVs in fracture healing. Lastly, the prospect of EVs for research and clinical use is discussed.

Abstract

The process of fracture healing is complex and requires an interaction of multiple organ systems. Cell-cell communication is known to be very important during this process. Extracellular vesicle (EVs) are small membranous vesicles generated from a variety of cells. Proteins, RNAs, small molecules and mitochondria DNA were found to be transported among cells through EVs. EV-based crosstalk represents a substantial cell-cell communication pattern, that can both interact with cells through molecular surfaces, and transfer molecules to cells. These interactions can assist in the synchronization of cellular functions among cells of the same kind, and coordinate the functions of different types of cells. After activation, platelets, neutrophils, macrophages, osteoblasts, osteoclasts, and mesenchymal stem cell (MSC) all secrete EVs, promoting the fracture healing process. Moreover, some studies have found evidence that EVs may be used for diagnosis and treatment of delayed fracture healing, and may be significantly involved in the pathophysiology of fracture healing disturbances. In this review, we summarize recent findings on: 1) EVs released by fracture healing-related cells, and 2) EV-mediated communications during fracture healing. We also highlight the potential applications of EVs in fracture healing. Lastly, the prospect of EVs for research and clinical use is discussed.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Department of Trauma Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:May 2018
Deposited On:29 Nov 2017 15:44
Last Modified:14 Apr 2018 01:00
Publisher:Lippincott Williams & Wilkins
ISSN:1073-2322
Additional Information:This is a non-final version of an article published in final form in Shock. 2017 Sep 27. doi: 10.1097/SHK.0000000000001002. [Epub ahead of print], Fracture Healing and the Underexposed Role of Extracellular Vesicle-Based Crosstalk, Qiao Z(1), Greven J, Horst K, Pfeifer R, Kobbe P, Pape HC, Hildebrand F.
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1097/SHK.0000000000001002
PubMed ID:28957874

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