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Impact of oral gut decontamination on staphylococcus aureus colonization in patients undergoing allogeneic hematopoietic stem cell transplantation


Wilk, C Matthias; Weber, Isabel; Seidl, Kati; Rachmühl, Carole; Holzmann-Bürgel, Anne; Müller, Antonia M S; Kuster, Stefan P; Schanz, Urs; Zinkernagel, Annelies S (2017). Impact of oral gut decontamination on staphylococcus aureus colonization in patients undergoing allogeneic hematopoietic stem cell transplantation. International Journal of Antimicrobial Agents, 50(6):726-729.

Abstract

Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P <0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.

Abstract

Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P <0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:7 August 2017
Deposited On:05 Oct 2017 12:53
Last Modified:15 Jun 2018 06:44
Publisher:Elsevier
ISSN:0924-8579
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.ijantimicag.2017.08.008
PubMed ID:28797807

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