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Evaluation of medication-related clinical decision support alert overrides in the intensive care unit


Wong, Adrian; Amato, Mary G; Seger, Diane L; Slight, Sarah P; Beeler, Patrick E; Dykes, Patricia C; Fiskio, Julie M; Silvers, Elizabeth R; Orav, E. John; Eguale, Tewodros; Bates, David W (2017). Evaluation of medication-related clinical decision support alert overrides in the intensive care unit. Journal of Critical Care, 39:156-161.

Abstract

Purpose: Medication-related clinical decision support (CDS) has been identified as a method to improve patient outcomes but is historically frequently overridden and may be inappropriately so. Patients in the intensive care unit (ICU) are at a higher risk of harm from adverse drug events (ADEs) and these overrides may increase patient harm. The objective of this study is to determine appropriateness of overridden medication-related CDS overrides in the ICU.
Materials and methods: We evaluated overridden medication-related alerts of four alert categories from January 2009 to December 2011. The primary outcome was the appropriateness of a random sample of overrides based on predetermined criteria. Secondary outcomes included the incidence of adverse drug events (ADEs) that re-sulted from the overridden alert.
Results: A total of 47,449 overridden alerts were included for evaluation. The appropriateness rate for overridden alerts varied by alert category (allergy: 94%, drug-drug interaction: 84%, geriatric: 57%, renal: 27%). A total of seven actual ADEs were identified in the random sample and where the medication(s) was administered (n = 366), with an increased risk of ADEs associated with inappropriately overridden alerts (p = 0.0078). Conclusions: The appropriateness of medication-related clinical decision support overrides in the ICU varied sub-stantially by the type of alert. Inappropriately overridden alerts were associated with an increased risk of ADEs compared to appropriately overridden alerts.

Abstract

Purpose: Medication-related clinical decision support (CDS) has been identified as a method to improve patient outcomes but is historically frequently overridden and may be inappropriately so. Patients in the intensive care unit (ICU) are at a higher risk of harm from adverse drug events (ADEs) and these overrides may increase patient harm. The objective of this study is to determine appropriateness of overridden medication-related CDS overrides in the ICU.
Materials and methods: We evaluated overridden medication-related alerts of four alert categories from January 2009 to December 2011. The primary outcome was the appropriateness of a random sample of overrides based on predetermined criteria. Secondary outcomes included the incidence of adverse drug events (ADEs) that re-sulted from the overridden alert.
Results: A total of 47,449 overridden alerts were included for evaluation. The appropriateness rate for overridden alerts varied by alert category (allergy: 94%, drug-drug interaction: 84%, geriatric: 57%, renal: 27%). A total of seven actual ADEs were identified in the random sample and where the medication(s) was administered (n = 366), with an increased risk of ADEs associated with inappropriately overridden alerts (p = 0.0078). Conclusions: The appropriateness of medication-related clinical decision support overrides in the ICU varied sub-stantially by the type of alert. Inappropriately overridden alerts were associated with an increased risk of ADEs compared to appropriately overridden alerts.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2017
Deposited On:05 Oct 2017 09:12
Last Modified:01 Jul 2018 00:06
Publisher:Elsevier
ISSN:0883-9441
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.jcrc.2017.02.027
PubMed ID:28259059

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